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The Truth About GLP-1 Agonists: Weight Loss, Side Effects, and Regaining Pounds *ONLINE ONLY*

January 2025

By Suzy Cohen, R.Ph.

What happens when you stop taking them? Are they safe long-term? This article will explore everything from eligibility to side effects, so you can make informed decisions.

To use GLP-1 agonists for weight loss, you need to have a BMI of 30 or higher. However, if your BMI is at least 27 and you have weight-related health issues like high blood pressure, high cholesterol, or type 2 diabetes, your doctor may still offer them to you.

GLP-1 agonists work by mimicking a hormone that controls blood sugar and appetite. They make you eat less by increasing satiety. These medications work only with consistent use, typically weekly injections. However, as with any drug, they come with potential risks and side effects.

GLP-1 agonists can cause some side effects the most common ones being nausea, vomiting, stomach pain and diarrhea. Eating smaller, slower meals and avoiding greasy foods may help. But for some, serious side effects to the pancreas or kidneys can occur. More recently, there appears to be an increased incidence of thyroid cancer in animal studies. On the bright side, having a healthy BMI can reduce risk for heart attacks.

Another consideration is nutrient depletion, a “drug mugger” effect where GLP-1 agonists can reduce levels of vital nutrients. It’s wise to supplement and the list of vitamins and minerals that you need is posted at my website, just use my search box.

One major drawback is that the weight loss isn’t permanent for many people. GLP-1 agonists suppress appetite and modify metabolism, but once you stop taking them, old habits—and the pounds—may return. Studies suggest up to two-thirds of the weight lost can come back within a year after discontinuation.

To maintain your progress, you’ll need to adopt lifestyle changes, such as portion control, regular exercise, and mindful eating. While long-term use of these medications is an option for some, it’s not a decision to take lightly due to cost, potential side effects, and the psychological aspect of reliance on a drug for weight control.

Should you try GLP-1 agonists? These drugs can be life-changing for people with type 2 diabetes which is sometimes accompanied with obesity, offering both weight loss and cardiovascular benefits. However, they’re not magic bullets. They work best as part of a comprehensive plan, and for short-term use. If you’re interested in a deeper dive into this topic, I’ve written a longer, more comprehensive blog on my website at suzycohen.com.

This information is not intended to treat, cure, or diagnose your condition. Always consult your physician for all medical matters. Visit www.SuzyCohen.com. ©2025 Suzy Cohen, R.Ph. Distributed by Dear Pharmacist, Inc.